| Duergar despot | 12 | Humanoid (dwarf) | Medium | 21 | 119 | | lawful evil | | Mordenkainen's Tome of Foes | | | | | | |
| Duergar kavalrachni | 2 | Humanoid (dwarf) | Medium | 16 | 26 | | lawful evil | | Mordenkainen's Tome of Foes | | | | | | |
| Duergar mind master | 2 | Humanoid (dwarf) | Medium | 14 | 39 | | lawful evil | | Mordenkainen's Tome of Foes | | | | | | |
| Duergar soulblade | 1 | Humanoid (dwarf) | Medium | 14 | 18 | | lawful evil | | Mordenkainen's Tome of Foes | | | | | | |
| Duergar stone guard | 2 | Humanoid (dwarf) | Medium | 18 | 39 | | lawful evil | | Mordenkainen's Tome of Foes | | | | | | |
| Duergar warlord | 6 | Humanoid (dwarf) | Medium | 20 | 75 | | lawful evil | | Mordenkainen's Tome of Foes | | | | | | |
| Duergar xarrorn | 2 | Humanoid (dwarf) | Medium | 18 | 26 | | lawful evil | | Mordenkainen's Tome of Foes | | | | | | |
| Duodrone | 0.25 | Construct | Medium | 15 | 11 | | lawful neutral | | Monster Manual | | | | | | |
| Dust mephit | 0.5 | Elemental | Small | 12 | 17 | fly | neutral evil | | Monster Manual (SRD) | 5 | 14 | 10 | 9 | 11 | 10 |
| Dybbuk | 4 | Fiend (demon) | Medium | 14 | 37 | fly | chaotic evil | | Mordenkainen's Tome of Foes | | | | | | |
| Eagle | 0 | Beast | Small | 12 | 3 | fly | unaligned | | Monster Manual (SRD) | 6 | 15 | 10 | 2 | 14 | 7 |
| Earth elemental | 5 | Elemental | Large | 17 | 126 | | neutral | | Monster Manual (SRD) | 20 | 8 | 20 | 5 | 10 | 5 |
| Earth elemental myrmidon | 7 | Elemental | Medium | 18 | 127 | | neutral | | Mordenkainen's Tome of Foes | | | | | | |
| Eblis | 1 | Monstrosity | Large | 13 | 26 | fly | neutral evil | | Adventures (Tomb of Annihilation) | | | | | | |
| Efreeti | 11 | Elemental | Large | 17 | 200 | fly | lawful evil | | Monster Manual (SRD) | 22 | 12 | 24 | 16 | 15 | 16 |
| Eidolon | 12 | Undead | Medium | 9 | 63 | fly | any alignment | | Mordenkainen's Tome of Foes | | | | | | |
| Elder brain | 14 | Aberration | Large | 10 | 210 | swim | lawful evil | Legendary | Volo's Guide to Monsters | | | | | | |
| Elder oblex | 10 | Ooze | Huge | 16 | 115 | | lawful evil | | Mordenkainen's Tome of Foes | | | | | | |
| Elder tempest | 23 | Elemental | Gargantuan | 19 | 264 | fly | neutral | | Mordenkainen's Tome of Foes | | | | | | |
| Elephant | 4 | Beast | Huge | 12 | 76 | | unaligned | | Monster Manual (SRD) | 22 | 9 | 17 | 3 | 11 | 6 |
| Elk | 0.25 | Beast | Large | 10 | 13 | | unaligned | | Monster Manual (SRD) | 16 | 10 | 12 | 2 | 10 | 6 |
| Empyrean | 23 | Celestial (titan) | Huge | 22 | 313 | fly, swim | chaotic good | Legendary | Monster Manual | | | | | | |
| Enchanter | 5 | Humanoid (any race) | Medium | 12 | 40 | | any alignment | | Volo's Guide to Monsters | | | | | | |
| Erinyes | 12 | Fiend (devil) | Medium | 18 | 153 | fly | lawful evil | | Monster Manual (SRD) | 18 | 16 | 18 | 14 | 14 | 18 |
| Ettercap | 2 | Monstrosity | Medium | 13 | 44 | | neutral evil | | Monster Manual (SRD) | 14 | 15 | 13 | 7 | 12 | 8 |