| Draegloth | 7 | Fiend (demon) | Large | 15 | 123 | | chaotic evil | | Volo's Guide to Monsters | | | | | | |
| Doppelganger | 3 | Monstrosity (shapechanger) | Medium | 14 | 52 | | neutral | | Monster Manual (SRD) | 11 | 18 | 14 | 11 | 12 | 14 |
| Dolphin | 0.12 | Beast | Medium | 12 | 11 | swim | unaligned | | Volo's Guide to Monsters | 14 | 13 | 13 | 6 | 12 | 7 |
| Djinni | 11 | Elemental | Large | 17 | 161 | fly | chaotic good | | Monster Manual (SRD) | 21 | 15 | 22 | 15 | 16 | 20 |
| Diviner | 8 | Humanoid (any race) | Medium | 12 | 67 | | any alignment | | Volo's Guide to Monsters | | | | | | |
| Displacer beast | 3 | Monstrosity | Large | 13 | 85 | | lawful evil | | Monster Manual | | | | | | |
| Dire wolf | 1 | Beast | Large | 14 | 37 | | unaligned | | Monster Manual (SRD) | 17 | 15 | 15 | 3 | 12 | 7 |
| Dire troll | 13 | Giant | Huge | 15 | 172 | | chaotic evil | | Mordenkainen's Tome of Foes | | | | | | |
| Dimetrodon | 0.25 | Beast | Medium | 12 | 19 | swim | unaligned | | Adventures (Tomb of Annihilation) | | | | | | |
| Dhergoloth | 7 | Fiend (yugoloth) | Medium | 15 | 119 | | neutral evil | | Mordenkainen's Tome of Foes | | | | | | |
| Devourer | 13 | Fiend | Large | 16 | 178 | | chaotic evil | | Volo's Guide to Monsters | | | | | | |
| Devilroot | 7 | Plant | Medium | 15 | 105 | | neutral evil | | Extra (AideDD) | 17 | 11 | 17 | 12 | 14 | 14 |
| Deva | 10 | Celestial | Medium | 17 | 136 | fly | lawful good | | Monster Manual (SRD) | 18 | 18 | 18 | 17 | 20 | 20 |
| Derro savant | 3 | Humanoid (derro) | Small | 13 | 36 | | chaotic evil | | Mordenkainen's Tome of Foes | | | | | | |
| Derro | 0.25 | Humanoid (derro) | Small | 13 | 13 | | chaotic evil | | Mordenkainen's Tome of Foes | | | | | | |
| Demogorgon | 26 | Fiend (demon) | Huge | 22 | 406 | swim | chaotic evil | | Mordenkainen's Tome of Foes | | | | | | |
| Demilich | 18 | Undead | Tiny | 20 | 80 | fly | neutral evil | Legendary | Monster Manual | | | | | | |
| Deinonychus | 1 | Beast | Medium | 13 | 26 | | unaligned | | Adventures (Tomb of Annihilation) | | | | | | |
| Deer | 0 | Beast | Medium | 13 | 4 | | unaligned | | Monster Manual (SRD) | 11 | 16 | 11 | 2 | 14 | 5 |
| Deep scion | 3 | Humanoid (shapechanger) | Medium | 11 | 67 | swim | neutral evil | | Volo's Guide to Monsters | | | | | | |
| Deep gnome svirfneblin | 0.5 | Humanoid (gnome) | Small | 15 | 16 | | neutral good | | Monster Manual (SRD) | 15 | 14 | 14 | 12 | 10 | 9 |
| Deathlock wight | 3 | Undead | Medium | 12 | 37 | | neutral evil | | Mordenkainen's Tome of Foes | | | | | | |
| Deathlock mastermind | 8 | Undead | Medium | 13 | 110 | | neutral evil | | Mordenkainen's Tome of Foes | | | | | | |
| Deathlock | 4 | Undead | Medium | 12 | 36 | | neutral evil | | Mordenkainen's Tome of Foes | | | | | | |
| Death tyrant | 14 | Undead | Large | 19 | 187 | fly | lawful evil | Legendary | Monster Manual | | | | | | |